Motif ID: SOX{8,9,10}.p2

Z-value: 1.576


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX9chr17_+_701171540.302.6e-01Click!
SOX10chr22_-_383798680.039.3e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_128841432 4.220 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr12_-_8815266 3.850 MFAP5
microfibrillar associated protein 5
chr7_-_27205148 3.706 NM_152739
HOXA9
homeobox A9
chr17_-_39743085 3.703 NM_000526
KRT14
keratin 14
chr7_-_27205123 3.428 HOXA9
homeobox A9
chr12_-_52886971 3.183 NM_005554
KRT6A
keratin 6A
chr2_+_102314162 2.700 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr12_-_8815370 2.490 NM_003480
MFAP5
microfibrillar associated protein 5
chr11_-_27494232 2.170 NM_018490
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr1_-_117210301 1.919 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr7_+_134464417 1.907 CALD1
caldesmon 1
chr10_-_105845619 1.899 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr1_+_153003677 1.848 NM_003125
SPRR1B
small proline-rich protein 1B
chrX_-_38079980 1.839 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr7_+_16793320 1.832 NM_014399
TSPAN13
tetraspanin 13
chr1_-_43424324 1.830 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr12_-_95611023 1.782 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr5_-_16936371 1.768 NM_012334
MYO10
myosin X
chr16_+_82660573 1.737 CDH13
cadherin 13, H-cadherin (heart)
chr1_-_94702916 1.732 ARHGAP29
Rho GTPase activating protein 29
chr12_-_8815479 1.717 MFAP5
microfibrillar associated protein 5
chr8_-_29206321 1.700 NM_057158
DUSP4
dual specificity phosphatase 4
chr2_-_151344145 1.697 NM_005168
RND3
Rho family GTPase 3
chr16_+_82660390 1.666 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr12_+_54378929 1.663 NM_017409
HOXC10
homeobox C10
chr10_-_105845556 1.640 COL17A1
collagen, type XVII, alpha 1
chr6_-_10415438 1.562 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr17_-_39942937 1.461 NM_002230
NM_021991
JUP

junction plakoglobin

chr1_-_153363544 1.444 NM_002964
S100A8
S100 calcium binding protein A8
chr10_+_71812356 1.425 NM_018649
H2AFY2
H2A histone family, member Y2
chr11_+_129991582 1.404 APLP2
amyloid beta (A4) precursor-like protein 2
chr5_+_148206155 1.365 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr9_+_706744 1.288 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr14_+_85996454 1.287 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr9_-_74383301 1.286 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr5_+_50679239 1.281 ISL1
ISL LIM homeobox 1
chr20_-_56285576 1.207 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr1_-_95392449 1.197 CNN3
calponin 3, acidic
chr10_+_71812536 1.195 H2AFY2
H2A histone family, member Y2
chr3_-_149688886 1.175 PFN2
profilin 2
chr3_-_185826748 1.157 NM_004454
ETV5
ets variant 5
chr17_-_38210611 1.155 MED24
mediator complex subunit 24
chr1_-_154946830 1.153 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr6_-_2840683 1.149 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr1_-_43424536 1.148 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr1_+_93913566 1.132 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr15_+_39873276 1.105 NM_003246
THBS1
thrombospondin 1
chr14_+_85996512 1.105 FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_-_68697997 1.092 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr18_+_3449972 1.088 NM_173209
NM_173208
NM_003244
TGIF1


TGFB-induced factor homeobox 1


chr4_-_186732047 1.077 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_-_15939949 1.076 FGFBP1
fibroblast growth factor binding protein 1
chr1_-_225840660 1.052 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr15_+_41136622 1.052 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr8_-_119123804 1.045 NM_000127
EXT1
exostosin 1
chr1_-_95392501 1.025 NM_001839
CNN3
calponin 3, acidic
chr7_-_107643330 1.020 NM_002291
LAMB1
laminin, beta 1
chr18_+_3451589 1.009 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr7_-_27135524 1.008 NM_005522
NM_153620
HOXA1

homeobox A1

chr1_-_154946801 1.004 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr1_-_94703252 1.003 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr1_-_154946859 0.995 NM_001130041
NM_001202859
NM_003029
SHC1


SHC (Src homology 2 domain containing) transforming protein 1


chr3_+_193853930 0.985 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr11_+_101983170 0.979 NM_001195045
YAP1
Yes-associated protein 1
chr2_-_31352489 0.958 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr19_-_55660557 0.953 NM_001126132
NM_001126133
NM_003283
TNNT1


troponin T type 1 (skeletal, slow)


chr7_+_77167351 0.950 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr17_-_1619473 0.943 MIR22HG
MIR22 host gene (non-protein coding)
chr10_-_123356158 0.939 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chrX_+_105937067 0.936 NM_024539
RNF128
ring finger protein 128
chr20_+_30193083 0.928 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr7_+_18535351 0.926 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr18_+_3447607 0.918 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr14_-_105444693 0.915 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr4_-_40936640 0.904 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr11_+_131780537 0.902 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr19_-_19051899 0.901 HOMER3
homer homolog 3 (Drosophila)
chr8_+_95653340 0.895 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr8_+_95653399 0.889 ESRP1
epithelial splicing regulatory protein 1
chr16_+_8768403 0.882 NM_020686
ABAT
4-aminobutyrate aminotransferase
chrX_+_102611379 0.877 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr22_-_19512859 0.873 NM_001130861
NM_003277
CLDN5

claudin 5

chr4_+_75310852 0.861 NM_001657
AREG
amphiregulin
chr17_+_42422665 0.858 GRN
granulin
chr18_-_21891469 0.855 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr18_+_11751470 0.845 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr6_+_121756744 0.843 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr7_+_12727204 0.833 ARL4A
ADP-ribosylation factor-like 4A
chr4_+_78078332 0.827 NM_004354
CCNG2
cyclin G2
chr10_+_102106771 0.827 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_+_35220647 0.820 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr4_+_78078394 0.810 CCNG2
cyclin G2
chr10_-_126107454 0.800 OAT
ornithine aminotransferase
chr5_+_40680021 0.794 NM_000958
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr5_+_50678957 0.785 NM_002202
ISL1
ISL LIM homeobox 1
chr3_+_57994087 0.784 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr4_-_186732208 0.766 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr1_-_85930610 0.765 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr21_+_18885104 0.764 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr3_+_193853937 0.762 HES1
hairy and enhancer of split 1, (Drosophila)
chr1_+_26503973 0.762 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr2_+_9346909 0.760 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr4_+_78079302 0.758 CCNG2
cyclin G2
chr19_+_35606731 0.756 NM_001136007
NM_001136008
NM_001136009
NM_001136010
NM_001136011
NM_001136012
NM_005971
NM_021910
FXYD3







FXYD domain containing ion transport regulator 3







chr17_+_42422627 0.747 GRN
granulin
chr18_+_55888799 0.744 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr7_-_111846384 0.743 NM_014705
DOCK4
dedicator of cytokinesis 4
chr4_-_7941092 0.729 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr1_-_27998719 0.729 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr9_-_14398981 0.729 NM_001190738
NFIB
nuclear factor I/B
chr16_-_84538219 0.722 NM_020947
KIAA1609
KIAA1609
chr18_+_55888838 0.719 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_86046434 0.718 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr11_+_60691911 0.718 NM_017870
NM_178031
TMEM132A

transmembrane protein 132A

chr5_+_74632992 0.717 NM_000859
NM_001130996
HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

chr12_-_6233684 0.713 NM_000552
VWF
von Willebrand factor
chr5_+_140739589 0.701 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr3_+_187871473 0.696 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr18_+_55711388 0.695 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr8_+_102504661 0.694 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr19_+_33864574 0.692 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr22_+_38142230 0.691 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr15_+_41136178 0.689 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr5_-_125930604 0.689 NM_001182
NM_001201377
NM_001202404
ALDH7A1


aldehyde dehydrogenase 7 family, member A1


chr10_-_33247178 0.676 NM_002211
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr10_-_126107493 0.664 NM_000274
NM_001171814
OAT

ornithine aminotransferase

chr3_-_149688638 0.662 NM_002628
NM_053024
PFN2

profilin 2

chr5_+_74633043 0.657 HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
chr15_+_99191671 0.657 IGF1R
insulin-like growth factor 1 receptor
chr10_+_73723992 0.654 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr7_-_41742666 0.653 NM_002192
INHBA
inhibin, beta A
chr10_+_5136589 0.650 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr3_+_187943192 0.646 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr8_+_95653272 0.635 ESRP1
epithelial splicing regulatory protein 1
chr7_+_12726910 0.630 NM_001195396
NM_005738
ARL4A

ADP-ribosylation factor-like 4A

chr14_+_59655351 0.628 NM_014992
DAAM1
dishevelled associated activator of morphogenesis 1
chr1_+_155294217 0.621 NM_014328
RUSC1
RUN and SH3 domain containing 1
chr1_-_205290756 0.616 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr7_+_134464372 0.614 CALD1
caldesmon 1
chr2_-_161056762 0.613 ITGB6
integrin, beta 6
chr11_+_12132063 0.611 NM_014632
MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
chr4_+_175204827 0.605 NM_001040157
CEP44
centrosomal protein 44kDa
chr16_+_28962127 0.603 NM_032815
NFATC2IP
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr8_+_94929082 0.601 NM_018444
NM_001161780
NM_001161779
NM_001161781
PDP1



pyruvate dehyrogenase phosphatase catalytic subunit 1



chr1_-_152297678 0.596 NM_002016
FLG
filaggrin
chr10_+_5136613 0.591 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr22_+_38142255 0.587 TRIOBP
TRIO and F-actin binding protein
chr10_+_5136556 0.587 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr5_-_127873734 0.582 NM_001999
FBN2
fibrillin 2
chr10_-_97321094 0.580 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr3_+_51422691 0.575 NM_006010
MANF
mesencephalic astrocyte-derived neurotrophic factor
chr22_+_38142316 0.574 TRIOBP
TRIO and F-actin binding protein
chr5_-_43313581 0.573 NM_001098272
NM_002130
HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr11_+_13299260 0.572 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr6_-_134639195 0.571 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_36621751 0.571 NM_018067
MAP7D1
MAP7 domain containing 1
chr8_+_104831415 0.561 NM_014677
RIMS2
regulating synaptic membrane exocytosis 2
chr3_+_50649292 0.555 NM_001243926
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr19_+_3094266 0.546 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr17_-_37764165 0.546 NM_006160
NEUROD2
neurogenic differentiation 2
chr17_-_39684585 0.546 NM_002276
KRT19
keratin 19
chr4_+_146403955 0.545 NM_001003688
SMAD1
SMAD family member 1
chr2_-_55277459 0.544 RTN4
reticulon 4
chr1_+_200708604 0.541 NM_203459
CAMSAP2
calmodulin regulated spectrin-associated protein family, member 2
chr3_+_189349215 0.540 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr11_-_79151694 0.539 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr2_-_55277592 0.539 RTN4
reticulon 4
chr6_+_83072922 0.539 NM_006670
TPBG
trophoblast glycoprotein
chr17_-_38210888 0.534 NM_001079518
NM_014815
MED24

mediator complex subunit 24

chr1_-_12677347 0.531 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr12_-_110318178 0.528 NM_016433
GLTP
glycolipid transfer protein
chr16_-_89556886 0.526 NM_013275
ANKRD11
ankyrin repeat domain 11
chr3_+_111717585 0.525 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr3_-_57583090 0.521 ARF4
ADP-ribosylation factor 4
chr12_-_81763127 0.521 NM_001220479
NM_001220480
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr1_+_155293727 0.519 NM_001105205
RUSC1
RUN and SH3 domain containing 1
chr11_+_13299349 0.515 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr3_-_139258531 0.514 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr11_+_13299329 0.512 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chrX_-_10535476 0.511 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr12_+_49212253 0.511 NM_000725
NM_001206915
CACNB3

calcium channel, voltage-dependent, beta 3 subunit

chr3_+_51422716 0.508 MANF
mesencephalic astrocyte-derived neurotrophic factor
chr2_-_55277672 0.507 RTN4
reticulon 4
chr18_+_55888750 0.507 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_154164551 0.504 NM_152263
TPM3
tropomyosin 3
chr2_-_55277698 0.504 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr15_+_71184781 0.502 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr13_+_110959592 0.498 NM_001846
COL4A2
collagen, type IV, alpha 2
chr7_+_16685757 0.497 NM_001159767
NM_014038
BZW2

basic leucine zipper and W2 domains 2

chr17_-_3571819 0.496 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr12_-_31479084 0.493 FAM60A
family with sequence similarity 60, member A
chr13_-_110959441 0.493 NM_001845
COL4A1
collagen, type IV, alpha 1
chr4_+_183245136 0.492 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr20_-_17662704 0.490 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr12_+_120933916 0.486 DYNLL1
dynein, light chain, LC8-type 1
chrX_+_48380163 0.486 NM_006579
EBP
emopamil binding protein (sterol isomerase)
chr11_-_66725790 0.481 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr8_+_26435339 0.481 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr2_-_132121730 0.479 NM_001077637
WTH3DI
RAB6C-like
chr20_-_17662828 0.477 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.12 5.15e-03 GO:0048598 embryonic morphogenesis
47.45 1.21e-02 GO:0007398 ectoderm development
3.97 2.66e-02 GO:0040011 locomotion
11.02 3.27e-02 GO:0034329 cell junction assembly

Nothing significant found in compartment category.

Nothing significant found in function category.